Hereditary Alpha Typtasemia Syndrome (HATS), as a published disorder, is in its infancy. No longitudinal, double-blind studies have been completed targeting treatments for HATS. In the meantime, treatments are generally borrowed from those used with Systematic Mastocytosis or other Mast Cell disorders.

Treatments for genetic causes

BLU-263 - Blueprint Medicines' trial for this medication is in progress, and as of 1/11/2021 has delivered "positive top-line results," moving it to phase 2, targeting "non-advanced systematic mastocytosis patients in mid-2021." Slides with more detail: here.

Treatments for anaphylaxis

The Mast Cell Disease Society maintains excellent resources for anaphylaxis, including an emergency room guide.

Recommended medications and supplements

In no particular order. Medications require trial and error. (Soon there will be source documentation for these recommendations.)

  • Cromolyn sodium, oral
  • Cromolyn sodium, nebulized
  • Zolair™️
  • Ketotifen (available compounded in the US; OTC, elsewhere)
  • H1s such as Zyrtec™️
  • H2s such as Pepcid™️ (previously, Zantac™️ was recommended in the US, but the Food and Drug Administration (FDA) recalled it in 2020.
  • Quercetin
  • Acetaminophen (for those who can tolerate NSAIDs)
  • Vitamin C



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